Despite the sizeable prevalence of sexually transmitted infections (STIs), the stigma experienced by individuals with STIs is enormous. These individuals can face both societal and self-stigma that are often not based on any scientific or evidence-based research, but rather cultural and social customs. This stigma has a considerable effect not only the mental and physical health of affected individuals but also creates barriers in communicating to partners and loved ones, getting tested, and receiving adequate treatment. In addition to increasing efforts in researching ways to eliminate this stigma and its associated burdens, structured psychoeducation and anti-stigma frameworks must be implemented to educate individuals on safe sexual practices and the ongoing and seriously taxing impact of stigma.