The isolation and quarantine policies implemented to limit the spread of the COVID-19 pandemic are a new and challenging experience for many people and may negatively impact mental health. By promoting resilience in the population, some of the impact of these vital public policies may be mitigated. The purpose of this article is to discuss the role of isolation measures implemented during the COVID-19 pandemic as stressors, which mediate impacts on the mental health of the general population and how strategies to increase resilience may serve to mitigate these effects.